Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES.

@article{Pastore2003TwoMF,
  title={Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES.},
  author={Cristina Pastore and Gaston Picchio and Francesco Galimi and Richard Fish and Oliver Cromwell . Hartley and Robin Ewart Offord and Donald E. Mosier},
  journal={Antimicrobial agents and chemotherapy},
  year={2003},
  volume={47 2},
  pages={
          509-17
        }
}
C-C chemokine receptor 5 (CCR5) is the primary coreceptor for human immunodeficiency virus type 1 (HIV-1) infection. Native chemokines that bind to CCR5 inhibit HIV-1 infection, albeit weakly, but chemically modified chemokines inhibit infection more efficiently. We have investigated the inhibitory mechanism of three N-terminally modified RANTES variants (AOP-, NNY-, and PSC-RANTES) with the MT-2 human T-cell line stably expressing either native or mutated CCR5. The RANTES analogues showed the… CONTINUE READING

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