Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma

@inproceedings{Li2015TwoMP,
  title={Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma},
  author={Xia Li and Yuexin Liu and Kirsi Granberg and Qinhao Wang and Lynette M. Moore and Ping Ji and Joy Gumin and Erik P. Sulman and George A. Calin and Hannu Kalervo Haapasalo and Matti Nykter and Ilya Shmulevich and Gregory N Fuller and Frederick F. Lang and Wei Zhang},
  booktitle={Oncogene},
  year={2015}
}
MIR-491 is commonly co-deleted with its adjacent CDKN2A on chromosome 9p21.3 in glioblastoma multiforme (GBM). However, it is not known whether deletion of MIR-491 is only a passenger event or has an important role. Small-RNA sequencing of samples from GBM patients demonstrated that both mature products of MIR-491 (miR-491-5p and -3p) are downregulated in tumors compared with the normal brain. The integration of GBM data from The Cancer Genome Atlas (TCGA), miRNA target prediction and reporter… CONTINUE READING