Two mammalian MOF complexes regulate transcription activation by distinct mechanisms.

@article{Li2009TwoMM,
  title={Two mammalian MOF complexes regulate transcription activation by distinct mechanisms.},
  author={Xiangzhi Li and Lipeng Wu and Callie Ann Sprunger Corsa and Steve Kunkel and Yali Dou},
  journal={Molecular cell},
  year={2009},
  volume={36 2},
  pages={290-301}
}
In mammals, MYST family histone acetyltransferase MOF plays important roles in transcription activation by acetylating histone H4 on K16, a prevalent mark associated with chromatin decondensation, and transcription factor p53 on K120, which is important for activation of proapoptotic genes. However, little is known about MOF regulation in higher eukaryotes. Here, we report that the acetyltransferase activity of MOF is tightly regulated in two different but evolutionarily conserved complexes… CONTINUE READING
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