Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes.

@article{Cordell1995TwolocusML,
  title={Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes.},
  author={Heather J. Cordell and John A. Todd and Simon T. Bennett and Yoshiharu Kawaguchi and Martin Farrall},
  journal={American journal of human genetics},
  year={1995},
  volume={57 4},
  pages={920-34}
}
To investigate the genetic component of multifactorial diseases such as type 1 (insulin-dependent) diabetes mellitus (IDDM), models involving the joint action of several disease loci are important. These models can give increased power to detect an effect and a greater understanding of etiological mechanisms. Here, we present an extension of the maximum lod score method of N. Risch, which allows the simultaneous detection and modeling of two unlinked disease loci. Genetic constraints on the… CONTINUE READING
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