Two liver-enriched trans-acting factors support the tissue-specific basal transcription from the rat tyrosine aminotransferase promoter

  title={Two liver-enriched trans-acting factors support the tissue-specific basal transcription from the rat tyrosine aminotransferase promoter},
  author={Ghislaine Schweizer-Groyer and André Groyer and Françoise Cadepond and Thierry Grange and Etienne Emile Baulieu and R. Pictet},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
A new cis-acting element involved in tissue-selective glucocorticoid inducibility of tyrosine aminotransferase gene expression.
The combined effects of this tissue-nonselective element and the above-mentioned tissue-selective element were to almost completely eliminate glucocorticoid inducibility in nonhepatic cells.
Cloning and Characterization of a Novel Binding Factor (GMEB-2) of the Glucocorticoid Modulatory Element*
The use of polymerase chain reaction of degenerate oligonucleotides and 5′- and 3′-rapid amplification of cDNA ends to clone two cDNAs of 2.0 and 1.9 kilobase pairs suggests that the 67-kDa GMEB-2 not only is an important factor for the modulation of glucocorticoid receptor bound to glucoc Corticoid response elements but also may belong to a novel family of transcription factors.
Major Histocompatibility Complex Class II-associated Invariant Chain Gene Expression Is Up-regulated by Cooperative Interactions of Sp1 and NF-Y (*)
A CCAAT box of imperfect sequence which binds NF-Y and activates transcription only when stabilized by an adjacent factor, Sp1 is defined, suggesting a mechanism for the complete functional synergy of the GC and CCAat elements observed in Ii transcription.
Basal and glucocorticoid induced changes of hepatic glucocorticoid receptor during aging: relation to activities of tyrosine aminotransferase and tryptophan oxygenase
The concentration (N) and dissociation constant (Kd) of glucocorticoid receptor (GR) significantly change during the aging both in untreated and dexamethasone treated animals and might play a role in the changes of the cell responses to glucoc Corticoid during the age.
Glucocorticoid receptors in ageing rats
Regulation of the HNF-1 homeodomain proteins by DCoH.


Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters.
The restricted expression of HNF1 and its selective interaction with the control regions of several liver-specific genes indicate that it is involved in developmentally regulated gene expression in the liver.
A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells.
In vitro transcription assays indicate that the binding of APF to its target sequence is required for albumin transcription and suggest that a modification in the primary structure of a transcription factor is correlated with the differentiated state of the hepatic cell.
Factors involved in specific transcription by human RNA polymerase II: analysis by a rapid and quantitative in vitro assay.
  • M. Sawadogo, R. Roeder
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1985
It is shown that three basic transcription factors, TFIIB, TFIID, and TFIIE, are absolutely required, in addition to the RNA polymerase II, for specific transcription initiation from the adenovirus major late promoter.
Several distinct "CCAAT" box binding proteins coexist in eukaryotic cells.
It is shown that a "CCAAT" box element present in the rat albumin promoter binds a protein distinct from the CCAAT-binding transcription factor CTF/NFI or from theCBP-binding protein (CBP) previously described.
Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?
Commentary Is CCAAT/enhancer-binding protein a central regulator of energy metabolism? Steven L. McKnight, M. Daniel Lane, and Salome Gluecksohn-Waelsch Research papers Localized surface activity of
Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes.
The expression of the tyrosine aminotransferase (TAT) gene of the rat was analyzed in primary hepatocytes and it was concluded that the two inducers affect transcription by independent mechanisms.