Two liver-enriched trans-acting factors support the tissue-specific basal transcription from the rat tyrosine aminotransferase promoter.

Abstract

The rat tyrosine aminotransferase gene (TAT) is a glucocorticoid-inducible gene, specifically expressed in liver. Using gel retardation assays, we have shown that its promoter (nt + 1 to -350; TAT.35) binds a combination of both ubiquitous and liver-specific trans-acting factors. Cis-acting sequences spanning: (i) nt -65 to -85 bound NF-Y, an ubiquitous… (More)

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@article{SchweizerGroyer1992TwoLT, title={Two liver-enriched trans-acting factors support the tissue-specific basal transcription from the rat tyrosine aminotransferase promoter.}, author={Ghislaine Schweizer-Groyer and Andr{\'e} Groyer and Françoise Cadepond and T. Grange and Etienne Emile Baulieu and R. Pictet}, journal={The Journal of steroid biochemistry and molecular biology}, year={1992}, volume={41 3-8}, pages={747-52} }