Two levels of resting potential in canine cardiac Purkinje fibers exposed to sodium-free solutions.

@article{Wiggins1976TwoLO,
  title={Two levels of resting potential in canine cardiac Purkinje fibers exposed to sodium-free solutions.},
  author={Jay R. Wiggins and Paul F. Cranefield},
  journal={Circulation research},
  year={1976},
  volume={39 4},
  pages={466-74}
}
Canine cardiac Purkinje fibers exposed to sodium-free solutions containing 16 mM CaCl2, 20 mM tetraethylammonium chloride, 108 mM tetramethylammonium chloride, and 2.7 mM KCl may be quiescent at a resting potential of either -50 mV or -90 mV. The membrane potential of these fibers can be switched from -50 mV to -90 mV by a hyperpolarizing current pulse and from -90 mV to -50 mV by a depolarizing current pulse. The transition from -50 mV to -90 mV depends on a voltage-dependent increase in… CONTINUE READING

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