Two-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies.

@article{Koutsopoulos2012TwolayeredIS,
  title={Two-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies.},
  author={Sotirios Koutsopoulos and Shuguang Zhang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={160 3},
  pages={451-8}
}
The release kinetics for human immunoglobulin (IgG) through the permeable structure of nanofiber scaffold hydrogels consisting of the ac-(RADA)(4)-CONH(2) and ac-(KLDL)(3)-CONH(2) self-assembling peptides were studied during a period of 3 months. Self assembling peptides are a class of stimuli-responsive materials which undergo sol-gel transition in the presence of an electrolyte solution such as biological fluids and salts. IgG diffusivities decreased with increasing hydrogel nanofiber density… CONTINUE READING
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