Two-layer membranes of calcium phosphate/collagen/PLGA nanofibres: in vitro biomineralisation and osteogenic differentiation of human mesenchymal stem cells.

@article{Hild2011TwolayerMO,
  title={Two-layer membranes of calcium phosphate/collagen/PLGA nanofibres: in vitro biomineralisation and osteogenic differentiation of human mesenchymal stem cells.},
  author={Nora Hild and Oliver Schneider and Dirk Mohn and Norman Albert Luechinger and Fabian M Koehler and Sandra Hofmann and Jolanda Rita Vetsch and Benjamin W. Thimm and Ralph M{\"u}ller and Wendelin J Stark},
  journal={Nanoscale},
  year={2011},
  volume={3 2},
  pages={401-9}
}
The present study evaluates the in vitro biomedical performance of an electrospun, flexible, anisotropic bilayer with one layer containing a collagen to mineral ratio similar to that in bone. The double membrane consists of a poly(lactide-co-glycolide) (PLGA) layer and an amorphous calcium phosphate (a-CaP)/collagen (Col)/PLGA layer. In vitro biomineralisation and a cell culture study with human mesenchymal stem cells (hMSC) were conducted to characterise such membranes for possible application… CONTINUE READING