Two kynurenine aminotransferases in human brain.

  title={Two kynurenine aminotransferases in human brain.},
  author={Etsuo Okuno and Masaya Nakamura and Robert M. Schwarcz},
  journal={Brain research},
  volume={542 2},
Using Tris-acetate buffer rather than conventional phosphate buffer, it was possible to detect two distinct proteins capable of producing the neuroinhibitory brain metabolite kynurenic acid (KYNA) from L-kynurenine in human brain tissue. The two kynurenine aminotransferases (KATs), arbitrarily termed 'KAT I' and 'KAT II', could be physically separated by… CONTINUE READING