Two isoforms of glutamate decarboxylase: why?

@article{Soghomonian1998TwoIO,
  title={Two isoforms of glutamate decarboxylase: why?},
  author={Jean-Jacques Soghomonian and David L. Martin},
  journal={Trends in pharmacological sciences},
  year={1998},
  volume={19 12},
  pages={
          500-5
        }
}
Adults express two isoforms of glutamate decarboxylase (GAD), GAD67 and GAD65, which are encoded by different independently regulated genes, a situation that differs from that of other neurotransmitters. In this article, J-J. Soghomonian and David Martin review current knowledge on the differences between these two isoforms. Both isoforms are present in most GABA-containing neurones in the CNS, but GAD65 appears to be targeted to membranes and nerve endings, whereas GAD67 is more widely… CONTINUE READING

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