Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3.

@article{Galoni2007TwoIF,
  title={Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3.},
  author={Danica P. Galoni{\'c} and Eric W. Barr and Christopher T Walsh and J Martin Bollinger and Carsten Krebs},
  journal={Nature chemical biology},
  year={2007},
  volume={3 2},
  pages={113-6}
}
Enzymatic incorporation of a halogen atom is a common feature in the biosyntheses of more than 4,500 natural products. Halogenation of unactivated carbon centers in the biosyntheses of several compounds of nonribosomal peptide origin is carried out by a class of mononuclear nonheme iron enzymes that require alpha-ketoglutarate (alphaKG, 1), chloride and oxygen. To investigate the ability of these enzymes to functionalize unactivated methyl groups, we characterized the chlorination of the gamma… CONTINUE READING
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