Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.
@article{Fitzpatrick2007TwoIR, title={Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.}, author={Teresa B. Fitzpatrick and Nikolaus Amrhein and Barbara Kappes and Peter Macheroux and Ivo Tews and Thomas Raschle}, journal={The Biochemical journal}, year={2007}, volume={407 1}, pages={ 1-13 } }
Vitamin B6 is well known in its biochemically active form as pyridoxal 5'-phosphate, an essential cofactor of numerous metabolic enzymes. The vitamin is also implicated in numerous human body functions ranging from modulation of hormone function to its recent discovery as a potent antioxidant. Its de novo biosynthesis occurs only in bacteria, fungi and plants, making it an essential nutrient in the human diet. Despite its paramount importance, its biosynthesis was predominantly investigated in…
165 Citations
Vitamin B6 Biosynthesis: Charting the Mechanistic Landscape
- BiologyChembiochem : a European journal of chemical biology
- 2010
This review will summarize and reflect on the recent efforts to unravel the mechanism of vitamin B6 biosynthesis with a particular emphasis on the most commonly utilized of the two routes.
Investigation of PDX1 and its role in a novel vitamin B6 biosynthesis pathway in Arabidopsis thaliana
- Biology, Environmental Science
- 2008
It is demonstrated that Arabidopsis thaliana has two functional homologs of PDX1 and a single homolog ofPDX2, and it is reported that the single PDX2 homolog is essential for plant.
Regulation of vitamin B6 biosynthesis in Arabidopsis thaliana
- Biology
- 2014
It is shown that increased levels of vitamin B6 can decrease the impact of singlet oxygen mediated oxidative stress in vivo and improve plant performance.
Discovery of pyridoxal reductase activity as part of human vitamin B6 metabolism.
- BiologyBiochimica et biophysica acta. General subjects
- 2019
A two‐step evolutionary process establishes a non‐native vitamin B6 pathway in Bacillus subtilis
- BiologyEnvironmental microbiology
- 2018
The existence of an underground metabolism in B. subtilis facilitates the generation of a pathway for synthesis of PLP using parts of a non-native vitamin B6 pathway, which could be helpful to generate pathways that might be optimized for producing valuable substances.
Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity
- BiologyPlant signaling & behavior
- 2016
It is shown that pdx3 mutants display a temperature-sensitive phenotype that is typical of autoimmune mutants and is possibly connected to the impaired nitrogen metabolism, suggesting an interaction between vitamin B6 and nitrogen metabolism.
Genes of the de novo and Salvage Biosynthesis Pathways of Vitamin B6 are Regulated under Oxidative Stress in the Plant Pathogen Rhizoctonia solani
- BiologyFront. Microbiol.
- 2016
The results suggest that accumulation of ROS in R. solani mycelia is linked to transcriptional regulation of the three genes and implicate the vitamin B6 biosynthesis machinery in R., solani, similar to catalases and GST, as an antioxidant stress protector against oxidative stress.
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