Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.

@article{Fitzpatrick2007TwoIR,
  title={Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.},
  author={T. Fitzpatrick and N. Amrhein and B. Kappes and P. Macheroux and I. Tews and Thomas Raschle},
  journal={The Biochemical journal},
  year={2007},
  volume={407 1},
  pages={
          1-13
        }
}
Vitamin B6 is well known in its biochemically active form as pyridoxal 5'-phosphate, an essential cofactor of numerous metabolic enzymes. The vitamin is also implicated in numerous human body functions ranging from modulation of hormone function to its recent discovery as a potent antioxidant. Its de novo biosynthesis occurs only in bacteria, fungi and plants, making it an essential nutrient in the human diet. Despite its paramount importance, its biosynthesis was predominantly investigated in… Expand
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  • 11
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  • 3
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  • 64
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  • 7
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  • 4
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References

SHOWING 1-10 OF 117 REFERENCES
Vitamin B6 biosynthesis in higher plants.
  • 171
  • PDF
On the Two Components of Pyridoxal 5′-Phosphate Synthase from Bacillus subtilis*
  • 109
  • PDF
Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond.
  • 19
Biosynthesis of vitamin B6 and structurally related derivatives.
  • 62
Reaction Mechanism of Pyridoxal 5′-Phosphate Synthase
  • 50
  • PDF
Structure of a bacterial pyridoxal 5′-phosphate synthase complex
  • 102
  • PDF
Recent progress of vitamin B6 biosynthesis.
  • 11
Evolution of vitamin B6 (pyridoxine) metabolism by gain and loss of genes.
  • 71
  • PDF
...
1
2
3
4
5
...