Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex.

Abstract

The Nef protein from the human immunodeficiency virus (HIV) induces down-regulation of the CD4 and major histocompatibility complex class I molecules from the cell surface by interfering with the endocytic machinery. This work focuses on the interaction of HIV-1 Nef with the mu 1 chain of adaptor protein type 1 (AP1) complex and its contribution to the Nef… (More)

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Cite this paper

@article{Erdtmann2000TwoIR, title={Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex.}, author={Luciana K Erdtmann and Katy Janvier and Graça Raposo and Heather M. Craig and Philippe Benaroch and Clarisse Berlioz-Torrent and John C. Guatelli and Rehab Benarous and Serge B{\'e}nichou}, journal={Traffic}, year={2000}, volume={1 11}, pages={871-83} }