Two independent mutational events in the loss of urate oxidase during hominoid evolution

  title={Two independent mutational events in the loss of urate oxidase during hominoid evolution},
  author={Xiangwei Wu and D. Muzny and Cheng Chi Lee and C. Thomas Caskey},
  journal={Journal of Molecular Evolution},
  • Xiangwei Wu, D. Muzny, +1 author C. Thomas Caskey
  • Published 2004
  • Biology, Medicine
  • Journal of Molecular Evolution
  • SummaryUrate oxidase was lost in hominoids during primate evolution. The mechanism and biological reason for this loss remain unknown. In an attempt to address these questions, we analyzed the sequence of urate oxidase genes from four species of hominoids: human (Homo sapiens), chimpanzee (Pan troglodytes), orangutan (Pongo pygmaeus), and gibbon (Hylobates). Two nonsense mutations at codon positions 33 and 187 and an aberrant splice site were found in the human gene. These three deleterious… CONTINUE READING
    399 Citations

    Paper Mentions

    Loss of urate oxidase activity in hominoids and its evolutionary implications.
    • 315
    • Highly Influenced
    • PDF
    Selective Pressure on the Allantoicase Gene During Vertebrate Evolution
    • 9
    Characterization of purine catabolic pathway genes in coelacanths.
    • 5
    The transthyretin-related protein family.
    • 71
    • PDF
    The genomes of the South American opossum (Monodelphis domestica) and platypus (Ornithorhynchus anatinus) encode a more complete purine catabolic pathway than placental mammals.
    • 11


    Mitochondrial DNA sequences of primates: Tempo and mode of evolution
    • 726
    • PDF
    Urate oxidase: primary structure and evolutionary implications.
    • 268
    • PDF
    The phylogeny of the hominoid primates, as indicated by DNA-DNA hybridization
    • 200
    On the loss of uricolytic activity during primate evolution--I. Silencing of urate oxidase in a hominoid ancestor.
    • 52
    Cloning the full-length cDNA for the porcine urate oxidase by the MOPAC generated probe.
    • 2
    Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.
    • 305
    • PDF
    Nonsense mutations in the human beta-globin gene affect mRNA metabolism.
    • S. Baserga, E. Benz
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1988
    • 183
    • PDF
    Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: liver-specific expression in the rat.
    • 27
    • PDF
    Urate oxidase in primate phylogenesis.
    • 62