Two independent mutational events in the loss of urate oxidase during hominoid evolution

@article{Wu2004TwoIM,
  title={Two independent mutational events in the loss of urate oxidase during hominoid evolution},
  author={Xiangwei Wu and D. Muzny and Cheng Chi Lee and C. Thomas Caskey},
  journal={Journal of Molecular Evolution},
  year={2004},
  volume={34},
  pages={78-84}
}
  • Xiangwei Wu, D. Muzny, +1 author C. Thomas Caskey
  • Published 2004
  • Biology, Medicine
  • Journal of Molecular Evolution
  • SummaryUrate oxidase was lost in hominoids during primate evolution. The mechanism and biological reason for this loss remain unknown. In an attempt to address these questions, we analyzed the sequence of urate oxidase genes from four species of hominoids: human (Homo sapiens), chimpanzee (Pan troglodytes), orangutan (Pongo pygmaeus), and gibbon (Hylobates). Two nonsense mutations at codon positions 33 and 187 and an aberrant splice site were found in the human gene. These three deleterious… CONTINUE READING
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