Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin.

@article{Mues1998TwoID,
  title={Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin.},
  author={Alexander Mues and P F van der Ven and Paul Young and Dieter O. F{\"u}rst and Mathias Gautel},
  journal={FEBS letters},
  year={1998},
  volume={428 1-2},
  pages={111-4}
}
The giant muscle protein titin/connectin plays a crucial role in myofibrillogenesis as a molecular ruler for sarcomeric protein sorting. We describe here that the N-terminal titin immunoglobulin domains Z1 and Z2 interact specifically with telethonin in yeast two-hybrid analysis and protein binding assays. Immunofluorescence with antibodies against the N-terminal region of titin and telethonin detects both proteins at the Z-disc of human myotubes. Longer titin fragments, comprising a serine… CONTINUE READING

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