Two-hybrid system as a model to study the interaction of beta-amyloid peptide monomers.

@article{Hughes1996TwohybridSA,
  title={Two-hybrid system as a model to study the interaction of beta-amyloid peptide monomers.},
  author={S R Hughes and Shefali Goyal and Jeff F. Sun and P. A. Gonzalez-DeWhitt and Maria Angela Henriques Zanella Fortes and Norbert Riedel and Samir Sahasrabudhe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 5},
  pages={2065-70}
}
The kinetics of amyloid fibril formation by beta-amyloid peptide (Abeta) are typical of a nucleation-dependent polymerization mechanism. This type of mechanism suggests that the study of the interaction of Abeta with itself can provide some valuable insights into Alzheimer disease amyloidosis. Interaction of Abeta with itself was explored with the yeast two-hybrid system. Fusion proteins were created by linking the Abeta fragment to a LexA DNA-binding domain (bait) and also to a B42… CONTINUE READING
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