Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.

  title={Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.},
  author={Ding Fang Bu and Mark G. Erlander and Benjamin C. Hitz and Niranjala J. K. Tillakaratne and Daniel L Kaufman and Caryn B Wagner-McPherson and G. A. Evans and Allan J. Tobin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 6},
We report the isolation and sequencing of cDNAs encoding two human glutamate decarboxylases (GADs; L-glutamate 1-carboxy-lyase, EC, GAD65 and GAD67. Human GAD65 cDNA encodes a Mr 65,000 polypeptide, with 585 amino acid residues, whereas human GAD67 encodes a Mr 67,000 polypeptide, with 594 amino acid residues. Both cDNAs direct the synthesis of enzymatically active GADs in bacterial expression systems. Each cDNA hybridizes to a single species of brain mRNA and to a specific set of… CONTINUE READING
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