Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos.

@article{Walter1994TwoHD,
  title={Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos.},
  author={Joachim Walter and Catherine Dever and Mark D. Biggin},
  journal={Genes & development},
  year={1994},
  volume={8 14},
  pages={1678-92}
}
We have used in vivo UV cross-linking to directly measure DNA binding by the homeo domain proteins even-skipped (eve) and fushi tarazu (ftz) in Drosophila embryos. Strikingly, these two proteins bind at uniformly high levels throughout the length of their genetically identified target genes and at lower, but significant, levels to genes that they are not expected to regulate. The data also suggest that these two proteins have very similar DNA-binding specificities in vivo. In contrast, a non… CONTINUE READING

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