Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment

@inproceedings{Martelli2012TwoHA,
  title={Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment},
  author={Alberto Maria Martelli and Francesca Chiarini and Camilla Evangelisti and Alessandra Cappellini and Francesca Buontempo and Daniela Bressanin and Milena Fini and James A McCubrey},
  booktitle={Oncotarget},
  year={2012}
}
Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell processes, that include differentiation, proliferation, apoptosis, autophagy, metabolism, motility, and exocytosis. However, constitutively active PI3K/Akt/mTOR signaling characterizes many types of tumors where it negatively influences response to therapeutic treatments. Hence… CONTINUE READING
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