Two glutathione S-transferase inhibitors from Radix Angelicae sinensis.

  title={Two glutathione S-transferase inhibitors from Radix Angelicae sinensis.},
  author={Feng Huang and Shaojing Li and Xinhua Lu and Ai-lin Liu and Guanhua Du and Ganggang Shi},
  journal={Phytotherapy research : PTR},
  volume={25 2},
Chemotherapy for malignant tumors fails because of multidrug resistance (MDR). The overexpression of glutathione S-transferase (GST) with MDR is considered one of the major obstacles to successful cancer chemotherapy. High-throughput screening was performed to search for inhibitors of GST from natural products. Two compounds isolated from Radix Angelicae sinensis had an inhibitory effect on GST, with 50% inhibitory concentration (IC(50) ) values of 16.80 and 7.30μm. Kinetic analyses showed that… CONTINUE READING
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