Two genes encode distinct glutamate decarboxylases.

@article{Erlander1991TwoGE,
  title={Two genes encode distinct glutamate decarboxylases.},
  author={Mark G. Erlander and Niranjala J. K. Tillakaratne and Sophie Feldblum and Neil D. Patel and Allan J. Tobin},
  journal={Neuron},
  year={1991},
  volume={7 1},
  pages={91-100}
}
gamma-Aminobutyric acid (GABA) is the most widely distributed known inhibitory neurotransmitter in the vertebrate brain. GABA also serves regulatory and trophic roles in several other organs, including the pancreas. The brain contains two forms of the GABA synthetic enzyme glutamate decarboxylase (GAD), which differ in molecular size, amino acid sequence, antigenicity, cellular and subcellular location, and interaction with the GAD cofactor pyridoxal phosphate. These forms, GAD65 and GAD67… CONTINUE READING
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