Two generations of insulinotropic imidazoline compounds.

@article{Efendc2002TwoGO,
  title={Two generations of insulinotropic imidazoline compounds.},
  author={Suad Efend{\'i}c and Alexander M. Efanov and P. -O. Berggren and Sergei V. Zaitsev},
  journal={Diabetes},
  year={2002},
  volume={51 Suppl 3},
  pages={S448-54}
}
The imidazoline RX871024 increased basal- and glucose-stimulated insulin release in vitro and in vivo. The compound inhibited activity of ATP-sensitive K(+) channels as well as voltage-gated K(+) channels, which led to membrane depolarization, an increase in the cytosolic Ca(2+) concentration ([Ca(2+)](i)), and insulin release. Importantly, RX871024 also enhanced the insulinotropic effect of glucose in cells with clamped [Ca(2+)](i) but in the presence of high ATP and Ca(2+)concentration inside… CONTINUE READING
23 Citations
50 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Ersnsberger P: Imidazoline receptors of the I1-subtype couple to phosphatidylcholine-selective phospholipase C in PC12 pheochromocytoma cells (Abstract)

  • D Separovic, M Keister, LA Colins
  • FASEB J 10:A416,
  • 1996
Highly Influential
5 Excerpts

Hypoglycemic action of 2-[2-(4,5-dihydro-1H FIG

  • K Kameda, S Ono, Y Abiko
  • From Diabetes Vol
  • 2001

Similar Papers

Loading similar papers…