Two-generation reproductive toxicity study of aluminium sulfate in rats.

  title={Two-generation reproductive toxicity study of aluminium sulfate in rats.},
  author={Mutsuko Hirata-Koizumi and Sakiko Fujii and Atsushi Ono and Akihiko Hirose and Toshio Imai and Kiyoshi Ogawa and Makoto Ema and A. Furukawa-K. Nishikawa},
  journal={Reproductive toxicology},
  volume={31 2},
In a two-generation reproductive toxicity study, male and female rats were given aluminium sulfate (AS) in drinking water at 0, 120, 600 or 3000 ppm. AS reduced water consumption in all treatment groups, and body weight was transiently decreased in the 3000 ppm group. In the F1 and F2 pups, preweaning body weight gain was inhibited at 3000 ppm, and the liver and spleen weight was decreased at weaning. At this dose, vaginal opening was slightly delayed. There were no compound-related changes in… CONTINUE READING


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