Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice.

  title={Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice.},
  author={Rochelle W. Tyl and Christina B Myers and Melissa C Marr and Carol S Sloan and Nora P Castillo and Michael M Veselica and John Curtis Seely and Stephen S. Dimond and John P. Van Miller and Ronald N. Shiotsuka and Dieter Beyer and Steven G. Hentges and John M. Waechter},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={104 2},
Dietary bisphenol A (BPA) was evaluated in a mouse two-generation study at 0, 0.018, 0.18, 1.8, 30, 300, or 3500 ppm (0, 0.003, 0.03, 0.3, 5, 50, or 600 mg BPA/kg/day, 28 per sex per group). A concurrent positive control group of dietary 17beta-estradiol (0.5 ppm; 28 per sex) confirmed the sensitivity of CD-1 mice to an endogenous estrogen. There were no BPA-related effects on adult mating, fertility or gestational indices, ovarian primordial follicle counts, estrous cyclicity, precoital… CONTINUE READING
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