Two-generation reproduction study and immunotoxicity screen in rats dosed with phenol via the drinking water.

@article{Ryan2001TwogenerationRS,
  title={Two-generation reproduction study and immunotoxicity screen in rats dosed with phenol via the drinking water.},
  author={B M Ryan and Rick Selby and Ralph Gingell and John M. Waechter and John H Butala and Stephen S. Dimond and B. J. Dunn and Robert James House and Robert Morrissey},
  journal={International journal of toxicology},
  year={2001},
  volume={20 3},
  pages={121-42}
}
This study evaluated the potential reproductive toxicity of phenol in a rat two-generation reproduction study, which included additional study endpoints, such as sperm count and motility, developmental landmarks, histological evaluation of suspect target organs (liver, kidneys, spleen, and thymus), weanling reproductive organ weights, and an immunotoxicity screening plaque assay. Phenol was administered to 30 Sprague-Dawley rats/sex/group in the drinking water at concentrations of 0, 200, 1000… CONTINUE READING

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