Two functionally different Na/K pumps in cardiac ventricular myocytes

@article{Gao1995TwoFD,
  title={Two functionally different Na/K pumps in cardiac ventricular myocytes},
  author={Jia-guo Gao and Richard T. Mathias and Ira S. Cohen and George J. Baldo},
  journal={The Journal of General Physiology},
  year={1995},
  volume={106},
  pages={995 - 1030}
}
The whole-cell patch-clamp technique was used to voltage clamp acutely isolated myocytes at -60 mV and study effects of ionic environment on Na/K pump activity. In quiescent guinea pig myocytes, normal intracellular Na+ is approximately 6 mM, which gives a total pump current of 0.25 +/- 0.09 pA/pF, and an inward background sodium current of 0.75 +/- 0.26 pA/pF. The average capacitance of a cell is 189 +/- 61 pF. Our main conclusion is the total Na/K pump current comprises currents from two… CONTINUE READING

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