Two forms of autosomal chronic granulomatous disease lack distinct neutrophil cytosol factors.

@article{Nunoi1988TwoFO,
  title={Two forms of autosomal chronic granulomatous disease lack distinct neutrophil cytosol factors.},
  author={Hiroyuki Nunoi and Daniel Rotrosen and John I. Gallin and Harry L Malech},
  journal={Science},
  year={1988},
  volume={242 4883},
  pages={1298-301}
}
Chronic granulomatous diseases of childhood (CGD) are a group of disorders of phagocytic cell superoxide (O2.-) production (respiratory burst). Anion exchange chromatography separated from normal neutrophil cytosol a 47-kilodalton neutrophil cytosol factor, NCF-1, that restored activity to defective neutrophil cytosol from most patients with autosomally inherited CGD in a cell-free O2.--generating system. A 65-kilodalton factor, NCF-2, restored activity to defective neutrophil cytosol from one… CONTINUE READING
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