Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.

@article{Brantley2010TwoFF,
  title={Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.},
  author={Scott J Brantley and Nicholas H Oberlies and David J. Kroll and Mary Paine},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={332 3},
  pages={1081-7}
}
Milk thistle (Silybum marianum) is a popular herbal product used for hepatoprotection and chemoprevention. Two commercially available formulations are the crude extract, silymarin, and the semipurified product, silibinin. Silymarin consists of at least seven flavonolignans, of which the most prevalent are the diastereoisomers silybin A and silybin B; silibinin consists only of silybin A and silybin B. Based on a recent clinical study showing an interaction between a silymarin product and the… CONTINUE READING
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