Two factors responsible for the development of denervation hypersensitivity.

@article{Jones1974TwoFR,
  title={Two factors responsible for the development of denervation hypersensitivity.},
  author={Rosemary E. Jones and Gerta Vrb{\'o}va},
  journal={The Journal of physiology},
  year={1974},
  volume={236 3},
  pages={517-38}
}
1. Innervated adult skeletal muscle is sensitive to acetylcholine at the end-plate region only. After denervation the entire muscle membrane becomes chemosensitive. The period of greatest increase in sensitivity in rat soleus muscles following section of the sciatic nerve in the thigh is between 48 and 72 hr post-operatively.2. Direct electrical stimulation was found to prevent the onset of the development of denervation hypersensitivity during the first 2-3 days after nerve section. Thereafter… CONTINUE READING

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