Two faces of cholecystokinin: anxiety and schizophrenia.

@article{Bourin1996TwoFO,
  title={Two faces of cholecystokinin: anxiety and schizophrenia.},
  author={Michel S Bourin and Myriam Malinge and Eero Vasar and Jacques Bradwejn},
  journal={Fundamental & clinical pharmacology},
  year={1996},
  volume={10 2},
  pages={
          116-26
        }
}
It has been suggested that cholecystokinin (CCK), a gut-brain peptide found in high concentrations in the mammalian brain, might be implicated in the neurobiology of anxiety and panic disorder. The administration of CCK tetrapeptide induced panic attacks analogous to spontaneous ones in patients suffering from panic disorder and to a lesser degree in healthy volunteers. In animal models of anxiety, the pretreatment with CCK agonists and antagonists produced, respectively, anxiogenic- and… CONTINUE READING
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