Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.

@article{Miyajima1989TwoEH,
  title={Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.},
  author={Naoko Miyajima and Ryuya Horiuchi and Yoko Shibuya and Shinichi Fukushige and Kenichi Matsubara and Kumao Toyoshima and Takashi Yamamoto},
  journal={Cell},
  year={1989},
  volume={57 1},
  pages={31-9}
}
Two erbA homologs, termed ear-1 and ear-7, are present in the human genome on chromosome 17. The two genes reside in the same genetic locus with overlapping exons and are transcribed from opposite DNA strands. In addition, the ear-7 mRNA is alternatively spliced to generate two protein isoforms, namely the ear71 and ear72 proteins. Nucleotide sequence analysis predicts that the ear71 protein is a human counterpart of the chicken c-erbA protein, a molecule closely related or identical to thyroid… CONTINUE READING
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