Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

@article{Miyajima1989TwoEH,
  title={Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus},
  author={Nobuyuki Miyajima and Ryuya Horiuchi and Yukiko Shibuya and Shinichi Fukushige and Ken-ichi Matsubara and Kumao Toyoshima and Tadashi Yamamoto},
  journal={Cell},
  year={1989},
  volume={57},
  pages={31-39}
}
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226 Citations
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226 Citations

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In the course of efforts to identify the neurofibromatosis type 1 gene (NF1), three genes were found embedded within an intron of NF1. The cDNA sequence of one of these genes (OMGP) encodes…
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References

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Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.
Two v-erbA-related genes, named ear-2 and ear-3, have been identified in the human genome and characterized by cDNA cloning. These genes are predicted to encode proteins that are very similar in…
Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone.
TLDR
The nucleotide and predicted amino acid sequences of two variant cDNAs showed virtual identity with the rat brain thyroid hormone receptor (rTR alpha) vI and vII, suggesting that the variants might have modulating functions in thyroid hormone action.
Two mammalian genes transcribed from opposite strands of the same DNA locus.
TLDR
The characterization of a genomic locus in the rat that encodes overlapping genes occupying both strands of the same piece of DNA, which encodes gonadotropin-releasing hormone and SH, is described.
A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library.
TLDR
It is shown that the erbA-T protein binds specifically to 3,5,3'-triiodo-L-thyronine with a dissociation constant of 3.8 +/- 0.2 x 10(-10) M, implying that more than one thyroid hormone receptor exists in humans and that these receptors might have different tissue- and gene-activating specificities.
Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes
A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.
  • A. Dayton, J. Selden, C. Croce
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
The apparent close proximity of the c-erbA sequences to the chromosomal breakpoints in these two leukemias suggests a possible role for this oncogene homologue in the development of these neoplasms.
Overlapping transcription units in the dopa decarboxylase region of Drosophila
TLDR
A quite different situation of overlap between the 3′ termini of a pair of convergent transcription units in another region of the Drosophila genome is reported, which raises the possibility that a hybrid molecule involving the two transcripts forms in vivo or that transcription interference occurs, with concomitant regulatory implications.
A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3′ ends
TLDR
The finding that the artificial introduction into cells of DNA constructs synthesizing anti-sense RNAs complementary to regions of mRNA transcribed from a chromosomal gene, can inhibit the gene's activity is discussed, presumably by the formation of double-stranded RNA.
Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription
TLDR
It is shown here that the rTRα1 receptor is a thyroid hormone-dependent transcriptional factor, which upon binding the T3 responsive element of the α-mHC gene, activates expression of this gene in vivo.
Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.
TLDR
Identification of human thyroid hormone receptor type alpha 2 indicates that two or more forms of thyroid hormone receptors exist in human tissues and may explain the normal variation in thyroid hormone responsiveness of various organs and the selective tissue abnormalities found in the thyroid hormone resistance syndromes.
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