Two enhancers and one silencer located in the introns of regA control somatic cell differentiation in Volvox carteri.

@article{Stark2001TwoEA,
  title={Two enhancers and one silencer located in the introns of regA control somatic cell differentiation in Volvox carteri.},
  author={Klaus J Stark and David B. Kirk and Ruediger Schmitt},
  journal={Genes & development},
  year={2001},
  volume={15 11},
  pages={1449-60}
}
The regA gene plays a central role in germ-soma differentiation of Volvox carteri by suppressing all reproductive functions in somatic cells. Here we show that the minimal promoter of regA consists of only 42 bp immediately upstream of the transcription start site, and that it contains no discernible regulatory elements. However, introns 3 and 5 are both required for regA expression in somatic cells, and intron 7 is essential for silencing regA in gonidia (asexual reproductive cells). A regA… CONTINUE READING
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