Two endothelin receptors (ETA and ETB) expressed on circular smooth muscle cells of guinea pig cecum.

@article{Okabe1995TwoER,
  title={Two endothelin receptors (ETA and ETB) expressed on circular smooth muscle cells of guinea pig cecum.},
  author={Hiroaki Okabe and Yoshiharu Chijiiwa and Kiyosi Nakamura and Mariko Yoshinaga and Hirotada Akiho and Naoaki Harada and Hajime Nawata},
  journal={Gastroenterology},
  year={1995},
  volume={108 1},
  pages={51-7}
}
BACKGROUND/AIMS The functional receptors for endothelin (ET) in colonic smooth muscle are still unknown. This study investigated the expression of ET receptors in isolated circular smooth muscle cells of guinea pig cecum. METHODS Inhibition of 125I-ET-1 binding was examined using unlabeled ET-1, ET-2, ET-3, sarafotoxin 6c (S6c), and ETA antagonists. Expression of the ET-receptor message was investigated using reverse-transcription polymerase chain reaction. The contractile potency of the ET… CONTINUE READING

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