Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint

@inproceedings{Miller2003TwoE1,
  title={Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint},
  author={Craig T. Miller and D. Yelon and D. Stainier and C. Kimmel},
  booktitle={Development},
  year={2003}
}
A conserved endothelin 1 signaling pathway patterns the jaw and other pharyngeal skeletal elements in mice, chicks and zebrafish. [...] Key Result First we show that edn1-expressing cells in the first (mandibular) and second (hyoid) pharyngeal arch primordia are located most ventrally and surrounded by hand2-expressing cells.Expand
edn1 and hand2 Interact in Early Regulation of Pharyngeal Arch Outgrowth during Zebrafish Development
TLDR
It is shown that in the early pharyngeal arches, ventral-specific edn1-mediated proliferation of neural crest derived cells is required for DV expansion and outgrowth, and that this positive regulation is counterbalanced by a negative one exerted through a pivotal, ventrally expressed Edn 1-target gene, hand2. Expand
Nkx2.5 regulates endothelin converting enzyme‐1 during pharyngeal arch patterning
TLDR
It is shown here that Nkx2.5 is required for proper craniofacial development in zebrafish and acts in part by upregulating ece1 expression, which illustrates a new function in embryonic development and provides new avenues with which to pursue potential mechanisms underlying human facial disorders. Expand
Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton
TLDR
It is demonstrated that morpholino (MO)-mediated knockdown in zebrafish of the highly conserved transcription factor grainyhead-like 3 (grhl3), which is selectively expressed in the pharyngeal endoderm, leads to severe hypoplasia of the lower jaw cartilages. Expand
phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish.
TLDR
It is shown that wild-type neural crest cells can efficiently rescue facial skeletal defects in homozygous plcbeta3 mutants, demonstrating that Plc beta3 function is required in neural crest Cells and not other cell types to pattern the facial skeleton. Expand
hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches
TLDR
It is indicated that the expression and function of hand2 and Dlx genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches. Expand
Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton
TLDR
A model in which later cross-inhibitory interactions between BMP and Edn1 signaling, in part mediated by Grem2, separate an initially homogenous ventral region into distinct ventral and intermediate skeletal precursor domains is proposed. Expand
Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development
TLDR
It is shown that the transcription factor SIX1 regulates dorsal arch development not only by inducing dorsal Jag1 expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA signaling. Expand
Evolution of oropharyngeal patterning mechanisms involving Dlx and endothelins in vertebrates.
TLDR
The results suggest that the last common ancestor of all the extant vertebrates would have possessed basic gene repertoires involved in oropharyngeal patterning in gnathostomes, but the elaborate genetic program leading to the Dlx code is likely to have been acquired uniquely in gnATHostomes. Expand
Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch.
TLDR
An integral role for ectoderm-derived Edn1 in early arch morphogenesis is illustrated, particularly in the intermediate domain, and an intermediate mandibular arch domain similar to the one defined in zebrafish is defined and it is shown that this region is most sensitive to loss of Edn 1. Expand
Conserved and unique transcriptional features of pharyngeal arches in the skate (Leucoraja erinacea) and evolution of the jaw.
TLDR
Broad conservation of dorsoventral patterning mechanisms are found within the developing mandibular, hyoid and gill arches of a cartilaginous fish, the skate, consistent with serial homology of their skeletal derivatives, as well as unique transcriptional features that may underpin distinct jaw and gills arch morphologies. Expand
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