Two endogenous neuropeptides modulate the gill and siphon withdrawal reflex in Aplysia by presynaptic facilitation involving cAMP-dependent closure of a serotonin-sensitive potassium channel.

Abstract

We have found that two endogenous neuropeptides in Aplysia, the small cardioactive peptides SCPA and SCPB, facilitate synaptic transmission from siphon mechano-sensory neurons and enhance the defensive withdrawal reflex that these sensory neurons mediate. Single-channel recording revealed that these peptides close a specific K+ channel, the S channel, which… (More)

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Cite this paper

@article{Abrams1984TwoEN, title={Two endogenous neuropeptides modulate the gill and siphon withdrawal reflex in Aplysia by presynaptic facilitation involving cAMP-dependent closure of a serotonin-sensitive potassium channel.}, author={Thomas W. Abrams and Vincent F. Castellucci and J S Camardo and Eric R Kandel and Philip E. Lloyd}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1984}, volume={81 24}, pages={7956-60} }