Two effects of lysophosphatidic acid on Ca(2+)-movement in cultured bovine adrenal chromaffin cells.

Abstract

We found that lysophosphatidic acid (LPA) exerted two effects on Ca(2+)-movement in cultured bovine adrenal chromaffin cells. At concentrations of above 10(-5) M, it induced slight, but significant 45Ca2+ influx, resulting in release of a small portion of stored catecholamine. At high concentrations it also significantly increased the intracellular Ca2… (More)

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