Two domains of the V protein of virulent canine distemper virus selectively inhibit STAT1 and STAT2 nuclear import.

@article{Rthlisberger2010TwoDO,
  title={Two domains of the V protein of virulent canine distemper virus selectively inhibit STAT1 and STAT2 nuclear import.},
  author={Anne R{\"o}thlisberger and Dominique J Wiener and Matthias Schweizer and Ernst Peterhans and Andreas Zurbriggen and Philippe Plattet},
  journal={Journal of virology},
  year={2010},
  volume={84 13},
  pages={6328-43}
}
Canine distemper virus (CDV) causes in dogs a severe systemic infection, with a high frequency of demyelinating encephalitis. Among the six genes transcribed by CDV, the P gene encodes the polymerase cofactor protein (P) as well as two additional nonstructural proteins, C and V; of these V was shown to act as a virulence factor. We investigated the molecular mechanisms by which the P gene products of the neurovirulent CDV A75/17 strain disrupt type I interferon (IFN-alpha/beta)-induced… CONTINUE READING
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