Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

@article{Katoh2001TwoDO,
  title={Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription},
  author={Y. Katoh and K. Itoh and E. Yoshida and M. Miyagishi and A. Fukamizu and M. Yamamoto},
  journal={Genes to Cells},
  year={2001},
  volume={6}
}
  • Y. Katoh, K. Itoh, +3 authors M. Yamamoto
  • Published 2001
  • Biology, Medicine
  • Genes to Cells
  • Background Nrf2 belongs to the Cap‐N‐Collar (CNC) transcription factor family and is essential for the antioxidant responsive element (ARE)‐mediated expression of a group of detoxifying and antioxidant genes. The forced expression of Nrf2 in mammalian cells activates the expression of target genes through the ARE, with Nrf2 showing the highest transactivation activity among the CNC family of transcription factors. To elucidate the molecular mechanisms generating this potent transactivation… CONTINUE READING
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