Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

  title={Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription},
  author={Y. Katoh and K. Itoh and E. Yoshida and M. Miyagishi and A. Fukamizu and M. Yamamoto},
  journal={Genes to Cells},
  • Y. Katoh, K. Itoh, +3 authors M. Yamamoto
  • Published 2001
  • Biology, Medicine
  • Genes to Cells
  • Background Nrf2 belongs to the Cap‐N‐Collar (CNC) transcription factor family and is essential for the antioxidant responsive element (ARE)‐mediated expression of a group of detoxifying and antioxidant genes. The forced expression of Nrf2 in mammalian cells activates the expression of target genes through the ARE, with Nrf2 showing the highest transactivation activity among the CNC family of transcription factors. To elucidate the molecular mechanisms generating this potent transactivation… CONTINUE READING
    359 Citations

    Topics from this paper

    Binding partners of NRF2: Functions and regulatory mechanisms.
    • 9
    RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.
    • 150
    • PDF
    The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation
    • 217
    • Highly Influenced
    • PDF
    Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
    • 263
    • PDF
    Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles
    • 679
    Methylation of arginine by PRMT1 regulates Nrf2 transcriptional activity during the antioxidative response.
    • X. Liu, H. Li, +7 authors J. Lu
    • Biology, Medicine
    • Biochimica et biophysica acta
    • 2016
    • 16
    Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.
    • 69
    • PDF


    Nrf2, a Cap’n’Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene*
    • 1,124
    • PDF
    Differential use of CREB binding protein-coactivator complexes.
    • 220
    Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
    • 2,656
    • PDF
    An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
    • 3,087
    Functional association between CBP and HNF4 in trans-activation.
    • 101
    Regulatory mechanisms of cellular response to oxidative stress.
    • 292
    Molecular Cloning and Functional Characterization of a New Cap’n’ Collar Family Transcription Factor Nrf3*
    • 253
    • PDF
    The CBP co-activator is a histone acetyltransferase
    • 1,762
    Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages*
    • 1,263
    • PDF