Two distinctly altered cellular responses to DNA double-strand breaks in human neuroblastoma.

  title={Two distinctly altered cellular responses to DNA double-strand breaks in human neuroblastoma.},
  author={X{\'e}nia Mergui and François Leteurtre and Marek Ireneusz Lipiński and Jean B{\'e}nard and Mounira Amor-Gu{\'e}ret},
  volume={90 11-12},
Neuroblastoma (NB), the most common extracranial solid tumors in children, presents with numerous genetic abnormalities that accumulate in a very short lifetime. To better understand this process, we have induced DNA double-strand breaks in NB cell lines and analyzed the activation of the ATM-H2AX/Chk2-p53 signaling pathway. We have found that NB cells could be classified into two distinct groups. The first group strongly expressed activated Chk2, displayed an important sub-G1 population… CONTINUE READING
8 Citations
54 References
Similar Papers


Publications citing this paper.
Showing 1-8 of 8 extracted citations


Publications referenced by this paper.
Showing 1-10 of 54 references


  • J. M. Maris, M. D. Hogarty, R. Bagatell, S. L. Cohn
  • Lancet 369 (9579)
  • 2007
Highly Influential
5 Excerpts


  • M. Hanada, S. Krajewski, S. Tanaka
  • Cazals-Hatem, B.A. Spengler, R.A. Ross, et al…
  • 1993
Highly Influential
5 Excerpts


  • M. Oliva-Trastoy, V. Berthonaud, A. Chevalier, C. Ducrot, M. C. Marsolier-Kergoat
  • Mann, et al., The Wip1 phosphatase (PPM1D…
  • 2007
2 Excerpts


  • H. Fujimoto, N. Onishi, N. Kato, M. Takekawa, X. Z. Xu
  • Kosugi, et al., Regulation of the antioncogenic…
  • 2006

Similar Papers

Loading similar papers…