Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

@article{Wrana1994TwoDT,
  title={Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.},
  author={Jeffrey L. Wrana and Hoanh Tran and Liliana Attisano and Kavita Arora and Stephen R. Childs and Joan Massagu{\'e} and Michael B O'connor},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 2},
  pages={944-50}
}
A transmembrane protein serine/threonine kinase, Atr-I, that is structurally related to receptors for members of the transforming growth factor-beta (TGF-beta) family has been cloned from Drosophila melanogaster. The spacing of extracellular cysteines and the cytoplasmic domain of Atr-I resemble most closely those of the recently described mammalian type I receptors for TGF-beta and activin. When expressed alone in test cells, Atr-I is unable to bind TGF-beta, activin, or bone morphogenetic… CONTINUE READING

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