Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.

@article{Shao2009TwoDR,
  title={Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.},
  author={Zhiyong Shao and Yi Zhang and Jo Anne Powell-Coffman},
  journal={Genetics},
  year={2009},
  volume={183 3},
  pages={821-9}
}
Oxygen is critically important to metazoan life, and the EGL-9/PHD enzymes are key regulators of hypoxia (low oxygen) response. When oxygen levels are high, the EGL-9/PHD proteins hydroxylate hypoxia-inducible factor (HIF) transcription factors. Once hydroxylated, HIFalpha subunits bind to von Hippel-Lindau (VHL) E3 ligases and are degraded. Prior genetic analyses in Caenorhabditis elegans had shown that EGL-9 also acted through a vhl-1-independent pathway to inhibit HIF-1 transcriptional… CONTINUE READING

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ROTH, 2009 C. elegans are protected from lethal hypoxia by an embryonic diapause

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