Two distinct p53 immunohistochemical patterns in human squamous-cell skin cancer, precursors and normal epidermis.

@article{Ren1996TwoDP,
  title={Two distinct p53 immunohistochemical patterns in human squamous-cell skin cancer, precursors and normal epidermis.},
  author={Z P Ren and Fredrik Pont{\'e}n and Monica Nist{\'e}r and Jan Pont{\'e}n},
  journal={International journal of cancer},
  year={1996},
  volume={69 3},
  pages={174-9}
}
Specimens of squamous-cell neoplasms (81 invasive cancers, 36 in situ cancers, 70 dysplasias, 5 keratoacanthomas, 19 papillomas) and normal skin were immunostained with p53 antibody. Nuclear accumulation of p53 was visualized as following 2 distinct patterns: dispersed or compact. The former is interpreted as a reversible reaction to sunlight, whereas the latter, after microdissection and sequencing of DNA, has been shown to reflect clonal multiplication of keratinocytes with mutated p53. The… CONTINUE READING
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