Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene.

@article{Ducy1995TwoDO,
  title={Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene.},
  author={Patricia Ducy and Gerard Karsenty},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 4},
  pages={1858-69}
}
Osteoblasts are cells of mesodermal origin that play a pivotal role during bone growth and mineralization. The mechanisms governing osteoblast-specific gene expression are still unknown. To understand these mechanisms, we analyzed the cis-acting elements of mouse osteocalcin gene 2 (mOG2), the best-characterized osteoblast-specific gene, by DNA transfection experiments in osteoblastic and nonosteoblastic cell lines and by DNA-binding assays. 5' deletion analysis of an mOG2 promoter-luciferase… CONTINUE READING
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