Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2.

@article{Lee2001TwoDN,
  title={Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2.},
  author={S K Lee and Soon Yong Jung and Y S Kim and So Young Na and Young chul Lee and Jae Woon Lee},
  journal={Molecular endocrinology},
  year={2001},
  volume={15 2},
  pages={
          241-54
        }
}
ASC-2 is a recently isolated transcriptional cointegrator molecule, which is amplified in human cancers and stimulates transactivation by nuclear receptors, AP-1, nuclear factor kappaB (NFkappaB), serum response factor (SRF), and numerous other transcription factors. ASC-2 contained two nuclear receptor-interaction domains, both of which are dependent on the integrity of their core LXXLL sequences. Surprisingly, the C-terminal LXXLL motif specifically interacted with oxysterol receptor LXRss… CONTINUE READING

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