Two distinct modulatory effects on calcium channels in adult rat sensory neurons.

@article{Formenti1993TwoDM,
  title={Two distinct modulatory effects on calcium channels in adult rat sensory neurons.},
  author={Alessandro Formenti and Elda Arrigoni and Mauro Mancia},
  journal={Biophysical journal},
  year={1993},
  volume={64 4},
  pages={1029-37}
}
D-ala2-D-leu5-enkephalin (100 to 1000 nM) reduces HVA Ca2+ currents of approximately 60% in 92% of the adult rat sensory neurons tested. In 80% of the cells sensitive to enkephalin, the reduction in Ca2+ current amplitude was associated with a prolongation of the current activation that was relieved by means of conditioning pulses in a potential range only about 10 mV positive to the current activation range in control conditions. The time course of the current activation was fitted to a single… CONTINUE READING