Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons.

@article{Dang2009TwoDM,
  title={Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons.},
  author={Vu C Dang and Ian Napier and Macdonald J Christie},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 10},
  pages={3322-7}
}
Sustained stimulation of G-protein coupled receptors (GPCRs) leads to rapid loss of receptor function (acute desensitization). For many GPCRs including the mu-opioid receptor (MOR), an accepted mechanism for acute desensitization is through G-protein coupled receptor kinase (GRKs) mediated phosphorylation of the receptor, which facilitates the binding of beta-arrestins (betaarrs) to the receptor and then promotes endocytosis. However, the mechanism(s) that mediate acute desensitization have not… CONTINUE READING

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  • 2001
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