Two distinct gating mechanisms in gap junction channels: CO2-sensitive and voltage-sensitive.

@article{Bukauskas1997TwoDG,
  title={Two distinct gating mechanisms in gap junction channels: CO2-sensitive and voltage-sensitive.},
  author={Feliksas F. Bukauskas and Camillo Peracchia},
  journal={Biophysical journal},
  year={1997},
  volume={72 5},
  pages={2137-42}
}
The chemical gating of single-gap junction channels was studied by the dual whole-cell voltage-clamp method in HeLa cells transfected with connexin43 (HeLa43) and in fibroblasts from sciatic nerves. Junctional current (Ij), single-channel conductance, and Ij kinetics were studied in cell pairs during CO2 uncoupling and recoupling at small transjunctional voltages (Vj < 35 mV: Vj gating absent) and at high Vj (Vj > 40 mV: Vj gating strongly activated). In the absence of Vj gating, CO2… CONTINUE READING

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