Two distinct forms of desensitization of G-protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide mu-opioid receptor agonists.

Abstract

Mu-opioid receptors (MORs) activate G-protein coupled inwardly rectifying potassium (GIRK) channels. The peptide agonist [D-Ala(2), NMe-Phe(4), Gly(5)-ol]enkephalin (DAMGO), but not the alkaloid morphine (MS), leads to acute desensitization of this response. Furthermore, DAMGO, as opposed to MS, triggers rapid internalization of MORs. Given this dichotomy… (More)

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Cite this paper

@article{Blanchet2003TwoDF, title={Two distinct forms of desensitization of G-protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide mu-opioid receptor agonists.}, author={Christophe Blanchet and Monica Sollini and Christian L{\"u}scher}, journal={Molecular and cellular neurosciences}, year={2003}, volume={24 2}, pages={517-23} }